Diabetic Neuropathy by Dr Obaidullah : Diabetic Neuropathy and Principles, Pathogenesis, and comprehensive Clinical Management by Dr Obaidullah

Diabetic neuropathy represents one of the most prevalent, disabling, and underrecognized complications of diabetes mellitus, contributing substantially to morbidity, mortality, and healthcare burden worldwide. It encompasses a heterogeneous group of disorders affecting sensory, motor, and autonomic components of the peripheral nervous system, arising from complex interactions between chronic hyperglycemia, metabolic dysregulation, microvascular injury, oxidative stress, and neurodegeneration. Despite advances in diabetes care, diabetic neuropathy remains largely irreversible once established, underscoring the critical importance of early recognition, prevention, and comprehensive management. This book provides a comprehensive, evidence-based, and clinically integrated account of diabetic neuropathy, designed as a postgraduate and doctoral-level reference for physicians, neurologists, endocrinologists, researchers, and medical trainees. Drawing upon authoritative sources including the World Health Organization, the American Diabetes Association, Harrison’s Principles of Internal Medicine, and contemporary peer-reviewed literature, the text bridges foundational science with bedside clinical practice. The volume systematically explores definitions, classifications, and epidemiology, followed by in-depth discussions on polyneuropathies, peripheral and central neuropathic disorders, and their age-, climate-, and geography-related variations. Detailed chapters elucidate pathophysiology, pathoanatomy, and pathogenesis at molecular, cellular, and neurovascular levels, providing a coherent understanding of disease mechanisms. Clinical sections emphasize symptomatology, diagnostic criteria, bedside and advanced investigations, differential diagnosis, and staging, supported by algorithms and illustrative diagrams. Preventive strategies, pharmacological and non-pharmacological treatments, and multidisciplinary management approaches are comprehensively addressed, with particular attention to painful diabetic neuropathy, autonomic dysfunction, foot complications, and prognostic implications. The book further includes high-yield examination pearls, case-based discussions, and extensively explained multiple-choice questions, making it a valuable resource for academic preparation and clinical decision-making. Ultimately, this work aims not only to inform but to inspire a holistic approach to diabetic neuropathy—one that integrates scientific rigor with clinical compassion—reinforcing the principle that the highest purpose of medical knowledge lies in the service of humanity. Read more